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Chronological Index of : Cover Story

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  • Figure: Healthcare/biotech fund flows

    'Perfect world' - for now Healthcare/biotech fund flows Buyside optimism about the overall healthcare space was reflected in the 3Q14 fund flows, as less than $1 million exited healthcare/biotech funds last quarter,…

    Published on 10/6/2014
  • Table: Follow-on performance

    'Perfect world' - for now Follow-on performance Reflecting the ability of biotechs to pad balance sheets with cash since the beginning of 2012, a modest $1 billion was raised via 21 follow-ons in 3Q14, fewer deals …

    Published on 10/6/2014
  • Table: IPO Performance

    'Perfect world' - for now IPO Performance Thirty companies raised more than $3 billion in IPOs in 3Q14. Excluding the $871.3 million raised by supply and services company Catalent Inc. (NYSE:CTLT) and the $509.8 …

    Published on 10/6/2014
  • Table: IPO queue

    'Perfect world' - for now IPO queue Twenty companies have announced plans to go public since the start of 3Q14, bringing the IPO queue to at least 39. Additionally, in 1Q14, China genomics company BGI Inc. said it …

    Published on 10/6/2014
  • 3Q14 Stock Wrap-Up: Going big again

    Winners, losers in biotech stock tiers in 3Q14

    For the second quarter in a row, only the large cap biotechs finished in the black in 3Q14.

    Published on 10/6/2014
  • Targeting PREA

    Advocates want Pediatric Research Equity Act to boost cancer treatments

    Oncologists and patient advocates want Pediatric Research Equity Act mandates to study new targeted cancer drugs in children.

    Published on 9/29/2014
  • Patching compassionate access

    Congress might move on compassionate access; wholesale reform looks unlikely

    Congress is gearing up to reconsider compassionate access to drugs, but wholesale reform looks unlikely.

    Published on 9/29/2014
  • Pandora's CVOT

    Contrave highlights data protection conundrum facing CV outcomes studies

    The Contrave case highlights the challenges of running a single CV outcomes trial to satisfy FDA while protecting the data.

    Published on 9/22/2014
  • Weighing in on obesity

    How Contrave and liraglutide could succeed in obesity

    The newest obesity drugs will have the weight of pharma companies behind them in the key cardiometabolic markets required for success.

    Published on 9/22/2014
  • Table: Obesity Runway

    Weighing in on obesity Obesity runway If Orexigen Therapeutics Inc. (NASDAQ:OREX), Takeda Pharmaceutical Co. Ltd. (Tokyo:4502) and Novo Nordisk A/S (CSE:NVO; NYSE:NVO) are successful in building physician awareness …

    Published on 9/22/2014
  • Cost and quality: Box: CMS bundles up

    Cancer: Cost and quality CMS bundles up CMS has signaled an interest in a bundled model for cancer reimbursement that would include physician services plus infused and outpatient drugs. The Medicare agency would not…

    Published on 9/15/2014
  • Cost and quality: Box: WellPoint's pathway

    Cancer: Cost and quality WellPoint's pathway WellPoint Inc. is piloting a treatment pathways program that dictates what drugs should be used based on tumor type and stage of disease. Clinicians who follow the …

    Published on 9/15/2014
  • Cancer: Cost and quality

    How cancer reimbursement reform could boost or inhibit drug use

    Payer reforms of cancer care may result in more drug use, depending on how the schemes balance cost-effectiveness and quality outcomes.

    Published on 9/15/2014
  • Betting big on hearts

    How Novartis built clinical case to replace generics in heart failure

    Novartis methodically built a clinical case to show doctors, patients and payers why LCZ696 should replace generics in heart failure.

    Published on 9/8/2014
  • Back to School Issue: Paying the piper

    22nd BioCentury Back to School Issue: Time to try new pricing schemes

    As the drumbeat for cost-based pricing grows louder, the 22nd Back to School essay says industry must experiment with new pricing models in which the cost of a given treatment is based on the patient-defined value of …

    Published on 9/1/2014
  • Box: Best price barrier

    Paying the piper Best price barrier The Medicaid best price rule for outpatient drugs is cited as a barrier to implementing new pricing models in the U.S. Companies that want an outpatient drug to be covered by …

    Published on 9/1/2014
  • Box: Big(ger) in Japan

    Paying the piper Big(ger) in Japan Drug prices in Japan are subject to mandatory reductions after launch, but there is an opportunity for companies to receive a premium, as well as for the price to be increased …

    Published on 9/1/2014
  • Box: Capping Orphans

    Paying the piper Capping Orphans Academics at Duke University have proposed a "grant-and-access" model for ultra-Orphan drugs based on the premise that high R&D costs are limiting investment in these rarest of …

    Published on 9/1/2014
  • Box: Code conundrum

    Paying the piper Code conundrum The U.S. drug coding system presents a challenge for companies that want to try flat pricing schemes. Once a drug is approved in the U.S., CMS establishes a code that connects the …

    Published on 9/1/2014
  • Box: Financing cures

    Paying the piper Financing cures Tanisha Carino of Avalere Health LLC and Scott Gottlieb of the American Enterprise Institute (AEI) both acknowledge that current pricing and reimbursement models are not structured …

    Published on 9/1/2014
  • Box: Pricing Cerdelga

    Paying the piper Pricing Cerdelga Finding U.S. Medicaid pricing regulations too limiting for a bolder experiment just yet, Genzyme Corp. is adopting a version of portfolio pricing lite for two Gaucher's drugs with …

    Published on 9/1/2014
  • Box: Sovaldi nightmares

    Paying the piper Sovaldi nightmares The great Sovaldi debate often overlooks that sofosbuvir is not so much more expensive than the previous standard of care. In interferon-containing regimens for treatment-naïve …

    Published on 9/1/2014
  • Box: Waiting for Kalydeco

    Paying the piper Waiting for Kalydeco Australian health authorities have proposed a pay-for-performance deal for Vertex Pharmaceuticals Inc.'s Kalydeco ivacaftor that would set per-patient reimbursement based on …

    Published on 9/1/2014
  • Figure: Out of room

    Paying the piper Out of room According to IMS Health Holdings Inc., worldwide drug expenditures are climbing out of the patent trough, suggesting that any "room" created by patent expirations was ephemeral. U.S. …

    Published on 9/1/2014
  • Figure: Uphill climb

    Paying the piper Uphill climb In the U.S., average wholesale price (AWP) often goes up even as competitors enter the market. The data below show price increases across five highly competitive categories. Three are …

    Published on 9/1/2014

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