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  • Table: PD-1 comps in melanoma

    Advantage, Merck PD-1 comps in melanoma Early data presented at ASCO suggest the lead mAbs against PD-1 receptor (PDCD1; PD-1; CD279) from Bristol-Myers Squibb Co. (NYSE:BMY) and Merck & Co. Inc. (NYSE:MRK) could …

    Published on 6/9/2014
  • Table: PD-1/PD-L1 comps in NSCLC

    Advantage, Merck PD-1/PD-L1 comps in NSCLC While early data presented at ASCO in non-small cell lung cancer (NSCLC) could appear to give nivolumab from Bristol-Myers Squibb Co. (NYSE:BMY) an efficacy advantage over …

    Published on 6/9/2014
  • Bladder breakthrough

    Genentech anti-PD-L1 immunotherapy could be 1st bladder cancer drug in 20 years

    Unlike its peers, Genentech has chosen metastatic bladder cancer as the lead indication for its anti-PD-L1 mAb. Based on Phase I data at ASCO, uptake in this underserved population could be swift.

    Published on 6/9/2014
  • Advantage, Merck

    How Merck may have advantage over BMS, AZ with PD-1/PD-L1 immunotherapies

    Data at ASCO show the three leading PD-1 and PD-L1 inhibitors have similar efficacy. Until more data are in, Merck looks to have the advantage based on dosing convenience in melanoma and toxicity in NSCLC.

    Published on 6/9/2014
  • Reforming oncology

    ASCO, payers taking different paths to cancer payment reform

    ASCO has made drug prices and value a centerpiece of its annual meeting, but private payers are coming up with more drug-centric approaches to cancer payment reform.

    Published on 6/2/2014
  • Box: Stumped

    Reforming oncology Stumped Jeffery Ward, an oncologist at Swedish Cancer Institute and chair of the ASCO payment reform working group, said the task force considered alternatives to buy-and-bill but couldn't arrive …

    Published on 6/2/2014
  • Europe's Iceberg 2014: Premier League teams

    BioCentury's 12th Iceberg survey: Top European companies need U.S. investors

    BioCentury's 12th annual European Iceberg survey finds the funding gap narrowing between the U.S. and European Premier League clubs. But to avoid relegation, top companies will need to aggressively pursue U.S. investors…

    Published on 5/26/2014
  • Figure: Clinical rationing

    Divergent appetites Clinical rationing Venture investors made triple-digit increases in funding for private companies with compounds in preclinical development or marketed products in 2013, while clinical stage …

    Published on 5/26/2014
  • Figure: Europe's total demand

    Divergent appetites Europe's total demand BioCentury projects that private and public European biotech companies with compounds in the clinic and beyond will need $5.7 billion over the next three years to keep their…

    Published on 5/26/2014
  • Figure: Private demand

    Divergent appetites Private demand Private European biotechs in the clinic and beyond will need an estimated $5.1 billion to support operations to the end of 2016, compared with a three-year estimate of $4.6 billion…

    Published on 5/26/2014
  • Figure: Public demand

    Divergent appetites Public demand Unprofitable public European biotechs in the clinic and beyond will need an estimated $585.8 million to support operations to the end of 2016 - the second lowest three-year demand …

    Published on 5/26/2014
  • Table: New funds

    Divergent appetites New funds Since the start of 2013, at least 15 life science funds with a European presence are raising or have raised a total of more than $4.5 billion. Deerfield Private Design Fund III tops the…

    Published on 5/26/2014
  • Box: The Cellectis experience

    Premier League teams The Cellectis experience When courting potential investors, the contents of the presentation - and the audience - can make all the difference. Such was the experience of Cellectis S.A. …

    Published on 5/26/2014
  • Figure: Capital rationing

    Premier League teams Capital rationing The top decile of private European money raisers elevated their game in 2013, averaging $63.3 million vs. $49.7 million in 2012, and better than matching the average of $62.3 …

    Published on 5/26/2014
  • Figure: EU vs. U.S. private raised

    Premier League teams EU vs. U.S. private raised Money raised by private European biotechs was up 48% to $1.7 billion in 2013 from $1.2 billion in 2012, while the U.S. saw a 17% decline to $3.9 billion from $4.7 …

    Published on 5/26/2014
  • Figure: EU vs. U.S. public raised

    Premier League teams EU vs. U.S. public raised Excluding debt, the top figure shows public biotechs in Europe increased their equity fundraising by 60% to $1.8 billion from 2012 vs. a 41% increase in the U.S. to $11…

    Published on 5/26/2014
  • Figure: Global competition for capital

    Premier League teams Global competition for capital Both Europe and the U.S. saw declines in total money raised from 2012 to 2013. However, excluding $1 billion-plus debt financings, the total raised in each region …

    Published on 5/26/2014
  • Table: Europe's premier league

    Premier League teams Europe's premier league By and large, the top 10% of private European fundraisers in 2013 were distinguished by differentiated technology platforms and therapeutic candidates, most of which …

    Published on 5/26/2014
  • Europe's Iceberg 2014: Divergent appetites

    Results of BioCentury's 12th Iceberg survey of funds needed by European biotech

    BioCentury's 12th annual European Iceberg survey projects the second-lowest financing demand ever for public biotechs. But private biotechs continue to demand more money due to a surge in Phase II players.

    Published on 5/26/2014
  • Exploding 340B

    How 340B discounts transfer billions from drug industry to hospitals

    Drug discounts under the 340B program are transferring growing billions of dollars from pharma P&Ls to hospitals. But it's increasingly apparent the money isn't going to support indigent care as envisioned.

    Published on 5/19/2014
  • Good news for dealmakers

    14B consumer health sale gives Merck firepower to expand BD&L deals

    While Merck continues its stepwise downsizing, the welcome mat is out for BD&L deals, especially in immune-oncology.

    Published on 5/12/2014
  • Reality show

    How Pfizer, AZ, Merck are putting their spin on "Big Thinker" deals

    The cast of this year's Pharma Big Thinkers drama all have different ideas for how to play the game.

    Published on 5/12/2014
  • Box: AstraZeneca makes its case

    Build up to break up AstraZeneca makes its case Last week, CEO Pascal Soriot asked investors in AstraZeneca plc for more time to execute his growth strategy and provided long-term projections he believes would be …

    Published on 5/12/2014
  • Build up to break up

    Why Pfizer needs AstraZeneca to make a break-up plan work

    Pfizer continues to give signals that the grand plan is to break itself up, and the reality looks like it absolutely needs AstraZeneca's assets to make it work.

    Published on 5/12/2014
  • Price to value reboot

    Whether NICE's new value metrics will ease cost-effectiveness hurdle for drugs

    NICE is adopting two value metrics from the U.K.'s failed value-based pricing scheme that could have eased the cost-effectiveness hurdle for new drugs. But for how many is unknown.

    Published on 5/5/2014

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