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Table: Cracking the combination
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Monday, October 22, 2012
New Phase II data show interferon-free combinations of
HCV therapeutics being developed by Abbott Laboratories (NYSE:ABT) and Bristol-Myers
Squibb Co. (NYSE:BMY) could produce sustained virologic response (SVR)
rates >90% in patients infected with HCV genotype 1 without the use of a
nucleotide-based NS5B inhibitor.
The best data previously reported were from Gilead
Sciences Inc. (NASDAQ:GILD) and BMS, which announced Phase II results in
April showing 100% sustained virologic response (SVR) in patients
receiving the nucleotide NS5B inhibitor sofosbuvir (GS-7977) and the NS5A
inhibitor daclatasvir. Gilead declined to advance the combination into Phase
III. The biotech is instead developing sofosbuvir with its own NS5A inhibitor,
GS-5855. Preliminary results from that combination are expected to be presented
at the American Association for the Study of Liver Diseases (AASLD) meeting
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