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Following Gilenya: How follow-on S1P agonists could mitigate CV effects in MS
Devil is in the dosing
By Erin McCallister
Senior Writer
Published on
Monday, May 28, 2012
Data released in April suggest the theory behind
second-generation sphingosine 1-phosphate receptor agonists in development for
multiple sclerosis was wrong. However, two companies are finding that improved
pharmacokinetics and/or dose titration could achieve the original goal of
improving safety compared with first-generation S1P receptor agonist Gilenya
fingolimod from Novartis
AG.
Gilenya, the first oral drug
for relapsing-remitting multiple sclerosis (RRMS), was approved in September
2010, but has struggled to gain a foothold in first-line use due to concerns
over cardiovascular safety (see BioCentury, Sept. 27, 2010).
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