OXFORD - Britain's bioscience sector, concluding a year of suffering at the hands of investors, is being gripped by a wave of personnel changes as shareholders look for individuals with appropriate skills to turn scientific ideas into businesses.

Last week two of Britain's most prominent entrepreneurial biotech founders announced that they were seeking new pastures, while the board at a third company, clearly frustrated by the fact that the scientific founder refuses to fall on his sword, is recommending he not be re-elected to the board.