Clinical results and plans

The AMGN paper

As reported by AMGN researchers, daily intraperitoneal injection of recombinant OB protein for 28 days lowered body weight in ob mutant mice by 22 percent from preinjection baseline at a 10 mg/kg dose (p<0.0001).

No significant change in weight was found in mice with two copies of the normal ob gene (+/+), although there was a trend towards weight loss. The protein was expressed in E. coli.