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Carolus Therapeutics Inc., San Diego, Calif. Product: CT-2009 Business: Pulmonary Indication: Treat acute lung injury In mouse models of acute lung injury, CT-2009 disrupted heteromers formed by the platelet-derived …
Published on 1/30/2012
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PolyMedix Inc. (OTCBB:PYMX), Radnor, Pa. Product: PMX-519, PMX519 Business: Infectious Indication: Treat candidiasis infections In mice infected with Candida albicans, a single topical dose of PMX-519 given 3 days after…
Published on 1/30/2012
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Cleveland BioLabs Inc. (NASDAQ:CBLI), Buffalo, N.Y. Product: CBLB613 Business: Other Indication: Treat acute radiation syndrome (ARS) In mice, CBLB613 protected against radiation-induced injury and significantly …
Published on 1/23/2012
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Phytopharm plc (LSE:PYM), Godmanchester, U.K. Product: Cogane (PYM50028) Business: Neurology Indication: Treat amyotrophic lateral sclerosis (ALS) In a rodent model of severe, late-stage ALS, once-daily oral Cogane for …
Published on 1/23/2012
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Colby Pharmaceutical Co., Menlo Park, Calif. Juvaris BioTherapeutics Inc., Burlingame, Calif. Product: Cationic liposome DNA complexes (CLDC) (JVRS-100) Business: Infectious Indication: Vaccinate against avian influenza…
Published on 1/16/2012
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Genentech Inc., South San Francisco, Calif. Roche (SIX:ROG; OTCQX:RHHBY), Basel, Switzerland Product: R1MAb Business: Endocrine/Metabolic Indication: Treat Type II diabetes In a mouse model of diabetes, a single …
Published on 1/9/2012
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Parsortix Inc., Philadelphia, Pa. Product: Parsortix cancer cell separation device Business: Diagnostic Indication: Capture circulating tumor cells (CTCs) In vitro, the Parsortix cancer cell separation device was able …
Published on 12/19/2011
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Arteria S.A., Caissargues, France Product: AP-5258 Business: Endocrine/Metabolic Indication: Treat postprandial hypertriglyceridemia In mice and rats, oral AP-5258 significantly inhibited the transfer of postprandial …
Published on 11/14/2011
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Betagenon AB, Stockholm, Sweden Product: O304 Business: Endocrine/Metabolic Indication: Treat obesity In obese diabetic mice, oral O304 significantly increased exercise endurance and promoted blood glucose disposal. In …
Published on 11/14/2011
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Geron Corp. (NASDAQ:GERN), Menlo Park, Calif. Product: GRNOPC1 Business: Autoimmune Indication: Treat multiple sclerosis (MS) In non-human primates, GRNOPC1 injected into demyelinated spinal cord lesions led to axon …
Published on 11/14/2011
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Hybrigenics S.A. (Euronext:ALHYG), Paris, France Product: HBX 19,818 Business: Cancer Indication: Treat chronic lymphocytic leukemia (CLL) In vitro, HBX 19,818 significantly reduced the cell number of all CLL primary …
Published on 11/14/2011
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ProtAffin AG, Graz, Austria Product: PA508 Business: Autoimmune Indication: Treat multiple sclerosis (MS) In a mouse model of experimental autoimmune encephalomyelitis (EAE), 40 g/kg PA508 significantly reduced disease …
Published on 11/14/2011
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Coridon Pty. Ltd., Buranda, Australia Product: O2-gD2 Business: Infectious Indication: Treat herpes simplex virus (HSV) type 2 infection In mice, O2-gD2 led to a >90% survival rate at day 21 following a high-dose HSV…
Published on 10/31/2011
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Genentech Inc., South San Francisco, Calif. Product: MEHD7945A Business: Cancer Indication: Treat cancer In mouse xenograft models of non-small cell lung cancer (NSCLC), MEHD7945A, a humanized IgG1 mAb targeting both …
Published on 10/31/2011
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Idera Pharmaceuticals Inc. (NASDAQ:IDRA), Cambridge, Mass. Product: GSO targeting APOB Business: Cardiovascular Indication: Treat cardiovascular disease In mice, subcutaneous administration of Idera's gene-silencing …
Published on 10/31/2011
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Idera Pharmaceuticals Inc. (NASDAQ:IDRA), Cambridge, Mass. Product: GSO targeting PCSK9 Business: Cardiovascular Indication: Treat cardiovascular disease In mice, subcutaneous administration of Idera's gene-silencing …
Published on 10/31/2011
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Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: Anti-CCR2-siRNA Business: Cancer, Cardiovascular Indication: Treat myocardial infarction (MI), atherosclerosis and lymphoma In a mouse model of MI, …
Published on 10/17/2011
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AstraZeneca plc (LSE:AZN; NYSE:AZN), London, U.K. Product: S. aureus anti-alpha toxin mAbs Business: Infectious Indication: Treat methicillin-resistant Staphylococcus aureus (MRSA) infection In mice with soft tissue …
Published on 10/17/2011
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Cellceutix Corp. (OTCQB:CTIX), Beverly, Mass. Product: Kevetrin Business: Cancer Indication: Treat prostate cancer In a mouse xenograft model of prostate cancer, 200 mg/kg intraperitoneal Kevetrin every other day for 3 …
Published on 10/17/2011
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Cellceutix Corp. (OTCQB:CTIX), Beverly, Mass. Product: KM-133 Business: Autoimmune Indication: Treat psoriasis In mouse xenograft models of psoriasis, KM-133 led to a faster reduction in lesion appearance and a …
Published on 10/17/2011
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Cleveland BioLabs Inc. (NASDAQ:CBLI), Buffalo, N.Y. Product: Protectan (CBLB502) Business: Renal Indication: Treat acute renal ischemic failure In mice, CBLB502 given 30 minutes before bilateral renal pedicle occlusion …
Published on 10/17/2011
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Eurocine Vaccines AB, Solna, Sweden Product: Endocine Business: Infectious Indication: Prevent influenza virus infection In ferrets, 3 doses of intranasal Endocine protected all animals against influenza infection in …
Published on 10/17/2011
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Laurantis Pharma Oy, Turku, Finland Product: Lymfactin (AdVEGF-C) Business: Inflammation Indication: Treat secondary lymphedema In a porcine model of lymphedema, Lymfactin given with autologous lymph node transfer …
Published on 10/17/2011
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MediGene AG (Xetra:MDG), Martinsried, Germany Product: AAVLP (HPV16/31L2) Business: Infectious Indication: Prevent HPV infection In mice and rabbits, adeno-associated virus-like particles (AAVLPs) presenting HPV minor …
Published on 10/17/2011
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ProtoKinetix Inc. (OTCBB:PKTX), Vancouver, B.C. Product: AAGP Business: Inflammation Indication: Treat eye inflammation In rats, 0.2% topical AAGP penetrated the protective barriers of the eye and was detected within …
Published on 10/17/2011