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Chronological Index of : Preclinical Results

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  • Blueprint Medicines preclinical data

    Blueprint Medicines, Cambridge, Mass. Product: BLU9931 Business: Cancer Indication: Treat hepatocellular carcinoma (HCC) In mouse xenograft models of fibroblast growth factor 19 (FGF19) amplified and FGF19 …

    Published on 4/21/2014
  • Celldex preclinical data

    Celldex Therapeutics Inc. (NASDAQ:CLDX), Needham, Mass. Product: CDX-014 (formerly CR014-vcMMAE) Business: Cancer Indication: Treat ovarian cancer and renal cell carcinoma (RCC) In mouse xenograft models of ovarian …

    Published on 4/21/2014
  • Genkyotex preclinical data

    Genkyotex S.A., Plan-les-Ouates, Switzerland Product: GKT137831 Business: Pulmonary Indication: Treat idiopathic pulmonary fibrosis (IPF) In aged mice with established pulmonary fibrosis, GKT137831 led to a reversal of …

    Published on 4/21/2014
  • MacroGenics preclinical data

    MacroGenics Inc. (NASDAQ:MGNX), Rockville, Md. Product: MGD007 Business: Cancer Indication: Treat colorectal cancer In a mouse xenograft model of colorectal cancer, doses as low as 4 g/kg IV MGD007 inhibited tumor …

    Published on 4/21/2014
  • NanoAntibiotics preclinical data

    NanoAntibiotics Inc., Surfside, Fla. Product: Efflux pump inhibitor Business: Infectious Indication: Treat bacterial infections In Staphylococcus epidermis bacteria incubated in vitro with tracer dye to monitor the …

    Published on 4/21/2014
  • OncoMed preclinical data

    OncoMed Pharmaceuticals Inc. (NASDAQ:OMED), Redwood City, Calif. Product: OMP-305B83 Business: Cancer Indication: Treat solid tumors OncoMed said OMP-305B83 showed significant in vivo antitumor efficacy in various solid…

    Published on 4/21/2014
  • Onconova Therapeutics preclinical data

    Onconova Therapeutics Inc. (NASDAQ:ONTX), Newton, Pa. Product: ON 1233000 Business: Cancer Indication: Treat mantle cell lymphoma (MCL) and multiple myeloma (MM) In a mouse xenograft model of MCL, once-daily 100 mg/kg …

    Published on 4/21/2014
  • OxiGene preclinical data

    OxiGene Inc. (NASDAQ:OXGN), South San Francisco, Calif. Product: KGP94 Business: Cancer Indication: Treat squamous cell carcinoma of the head and neck (SCCHN) In a mouse model of SCCHN, KGP94 significantly delayed tumor…

    Published on 4/21/2014
  • Regulus preclinical data

    Regulus Therapeutics Inc. (NASDAQ:RGLS), San Diego, Calif. Product: Anti-miR-221 Business: Cancer Indication: Treat hepatocellular cancer (HCC) In a mouse xenograft model of HCC, thrice-weekly subcutaneous 25 mg/kg anti…

    Published on 4/21/2014
  • Seattle Genetics preclinical data

    Seattle Genetics Inc. (NASDAQ:SGEN), Bothell, Wash. Product: SGN-CD70A Business: Cancer Indication: Treat cancer In renal cell carcinoma (RCC) and non-Hodgkin's lymphoma (NHL) cell lines, SGN-CD70A induced targeted cell…

    Published on 4/21/2014
  • TherapeuticsMD preclinical data

    TherapeuticsMD Inc. (NYSE-M:TXMD), Boca Raton, Fla. Product: Estradiol VagiCap (TX 004-HR) (formerly TX 12-004-HR) Business: Endocrine/Metabolic Indication: Treat moderate to severe symptoms of vulvar and vaginal …

    Published on 4/21/2014
  • Idenix preclinical data

    Idenix Pharmaceuticals Inc. (NASDAQ:IDIX), Cambridge, Mass. Product: IDX21437 Business: Infectious Indication: Treat HCV infection In HCV cell-based assays, IDX21437 selectively inhibited HCV replicons. Idenix also said…

    Published on 4/7/2014
  • Isis Pharmaceuticals preclinical data

    Isis Pharmaceuticals Inc. (NASDAQ:ISIS), Carlsbad, Calif. Product: ISIS-HBVRx (formerly ISIS-GSK3Rx) Business: Infectious Indication: Treat HBV infection In a mouse model of HBV infection, subcutaneous doses of >=11 …

    Published on 4/7/2014
  • Patrys preclinical data

    Patrys Ltd. (ASX:PAB), Melbourne, Australia Product: PAT-LM1 Business: Cancer Indication: Treat lymphoma In vitro, PAT-LM1 induced cell death in mantle cell lymphoma (MCL) and histiocytic lymphoma cells. Patrys declined…

    Published on 4/7/2014
  • Novogen preclinical data

    Novogen Ltd. (ASX:NRT; NASDAQ:NVGN), Hornsby, Australia Product: Trilexium (Trx-1) Business: Cancer Indication: Treat ovarian cancer In a mouse xenograft model of ovarian cancer, Trx-1 significantly reduced tumor growth…

    Published on 3/31/2014
  • BioCryst preclinical data

    BioCryst Pharmaceuticals Inc. (NASDAQ:BCRX), Durham, N.C. Product: BCX4430 Business: Infectious Indication: Treat Marburg virus infection In cynomolgus macaques infected with a lethal dose of Marburg virus, twice-daily …

    Published on 3/17/2014
  • Synta preclinical data

    Synta Pharmaceuticals Corp. (NASDAQ:SNTA), Lexington, Mass. Product: HDC docetaxel (STA-9183) Business: Cancer Indication: Treat solid tumors In mouse xenograft models of triple-negative breast cancer (TNBC) and non-…

    Published on 3/10/2014
  • Synta preclinical data

    Synta Pharmaceuticals Corp. (NASDAQ:SNTA), Lexington, Mass. Product: HDC SN-38 (STA-12-8666) Business: Cancer Indication: Treat solid tumors In mouse xenograft tumor models, STA-12-8666 safely delivered >10 times …

    Published on 3/10/2014
  • Angiochem preclinical data

    Angiochem Inc., Montreal, Quebec Product: ANG2002 Business: Neurology Indication: Treat pain In rat models of neuropathic and bone cancer pain, 0.05 mg/kg ANG2002 significantly reduced pain behaviors vs. vehicle-treated…

    Published on 3/3/2014
  • AngioGenex preclinical data

    AngioGenex Inc. (Pink:AGGX), New York, N.Y. Product: Idantirx (AGX-51) Business: Cancer Indication: Treat cancer In a mouse model of breast cancer, twice-daily AGX-51 significantly blocked tumor growth at a dose <7 …

    Published on 3/3/2014
  • Biokine, BioLineRx preclinical data

    Biokine Therapeutics Ltd., Tel Aviv, Israel BioLineRx Ltd. (Tel Aviv:BLRX; NASDAQ:BLRX), Jerusalem, Israel Product: BL-8040 (formerly BKT-140) Business: Cancer Indication: Treat chronic myelogenous leukemia (CML) In …

    Published on 3/3/2014
  • Epizyme, Eisai preclinical data

    Epizyme Inc. (NASDAQ:EPZM), Cambridge, Mass. Eisai Co. Ltd. (Tokyo:4523), Tokyo, Japan Product: EPZ-6438, E7438 Business: Cancer Indication: Treat non-Hodgkin's lymphoma (NHL) In a mouse xenograft model of enhancer of …

    Published on 3/3/2014
  • Marina Biotech, Mirna preclinical data

    Marina Biotech Inc. (OTCQX:MRNA), Bothell, Wash. Mirna Therapeutics Inc., Austin, Texas Product: MRX34, miR-34 (formerly miR-Rx34) Business: Cancer Indication: Treat non-small cell lung cancer (NSCLC) and hepatocellular…

    Published on 3/3/2014
  • Vivolux preclinical data

    Vivolux AB, Uppsala, Sweden Product: VLX600 Business: Cancer Indication: Treat solid tumors In a mouse xenograft model of colorectal cancer, IV 16 mg/kg VLX600 given every 3 days for 16 days significantly inhibited …

    Published on 3/3/2014
  • BerGenBio, Rigel preclinical data

    BerGenBio A/S, Bergen, Norway Rigel Pharmaceuticals Inc. (NASDAQ:RIGL), South San Francisco, Calif. Product: BGB324 (formerly R428) Business: Cancer Indication: Treat non-small cell lung cancer (NSCLC) In a mouse …

    Published on 2/24/2014

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