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Chronological Index of : Preclinical Results

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  • AVI preclinical data

    AVI BioPharma Inc. (AVII), Portland, Ore. Product: Esprit against dystrophin Indication: Treat Duchenne muscular dystrophy (DMD) In a mouse model of DMD, IV injections of Esprit induced expression of functional levels …

    Published on 2/13/2006
  • Ceragenix preclinical data

    Ceragenix Pharmaceuticals Inc. (CGXP), Denver, Colo. Product: CSA-54 Indication: Treat HIV In various in vitro studies in multiple strains of HIV, CSA-54 inhibited HIV infection of primary human CD4 T cells, a target …

    Published on 2/13/2006
  • ReNeuron Ltd. preclinical data

    ReNeuron Ltd. (LSE:RENE), London, U.K. Product: ReN001 Indication: Treat stroke In a rodent model of stroke, ReN001 led to a dose-dependent reversal of both sensory and motor symptoms associated with stroke disability. …

    Published on 2/13/2006
  • Bio-Bridge preclinical data

    Bio-Bridge Science Inc. (BGES), Oak Brook, Ill. Product: HIV-PV pseudovirus vaccine Indication: HIV/AIDS Researchers reported that low, medium and high doses of HIV pseudovirus (HIV-PV) vaccine did not have any side …

    Published on 2/6/2006
  • CytRx preclinical data

    CytRx Corp. (CYTR), Los Angeles, Calif. Product: siRNA against RIP140 Indication: Treat obesity and Type II diabetes Researchers published in the Journal of Clinical Investigation that RIP140 depletion upregulates the …

    Published on 2/6/2006
  • Prana preclinical data

    Prana Biotechnology Ltd. (ASX:PBT; PRAN), Melbourne, Australia Product: Clioquinol (PBT-1) Indication: Diagnose Alzheimer's disease (AD) Researchers published in Aging Cell that radioiodinated clioquinol could be used …

    Published on 2/6/2006
  • Cytogen preclinical data

    Cytogen Corp. (CYTO), Princeton, N.J. Product: Quadramet Indication: Treat multiple myeloma (MM) In a mouse model of myeloma, Quadramet as monotherapy significantly prolonged median survival to 28 days vs. untreated …

    Published on 1/30/2006
  • Edwards, Sangamo preclinical data

    Edwards Lifesciences Corp. (EW), Irvine, Calif. Sangamo BioSciences Inc. (SGMO), Richmond, Calif. Product: ZFP TF Indication: Treat critical limb ischemia (CLI) In mouse model of CLI, vascular endothelial growth factor…

    Published on 1/30/2006
  • Phosphagenics preclinical data

    Phosphagenics Ltd. (ASX:POH; LSE:PSG), Melbourne, Australia Product: GTP-0805 Indication: Treat prostate cancer and breast cancer In vitro studies showed that GTP-0805 induced >90% reduction in prostate cancer cells.…

    Published on 1/30/2006
  • AVI preclinical data

    AVI BioPharma Inc. (AVII), Portland, Ore. Product: Neugene antisense against Ebola virus Indication: Prevent Ebola virus infection Researchers showed that Neugene agents against Ebola virus protected rodents in both pre…

    Published on 1/23/2006
  • Galapagos NV preclinical data

    Galapagos NV (Euronext:GLPG; LSE:GLPG), Mechelen, Belgium Product: G002486 Indication: Treat rheumatoid arthritis (RA) In a mouse model of RA, 40 mg/kg G002486, a disease-modifying agent (DMARD), led to a significant …

    Published on 1/23/2006
  • Amarin preclinical data

    Amarin Corp. plc (AMRN), London, U.K. Product: Miraxion (LAX-101) Indication: Treat Parkinson's disease (PD) In vitro studies in cell lines associated with PD showed that Miraxion demonstrated neuroprotective effects by…

    Published on 1/16/2006
  • BioSyntech preclinical data

    BioSyntech Inc. (TSX-V:BSY), Laval, Quebec Product: BST-CarGel Indication: Cartilage repair BSY published in The Journal of Bone and Joint Surgery that, in sheep with damaged cartilage in the knees, BST-CarGel led to …

    Published on 1/16/2006
  • Emergent BioSolutions preclinical data

    Emergent BioSolutions Inc., Gaithersburg, Md. Product: BioThrax Indication: Treat inhalation anthrax In a non-human primate model of anthrax infection, post-infection BioThrax vaccination plus antibiotics gave 100% …

    Published on 1/16/2006
  • Peregrine preclinical data

    Peregrine Pharmaceuticals Inc. (PPHM), Tustin, Calif. Product: Tarvacin (3G4) Indication: Treat pancreatic cancer In a mouse model of pancreatic cancer, Tarvacin with gemcitabine combination reduced tumor burden 3- to 5…

    Published on 1/16/2006
  • Scil preclinical data

    Scil Group, Martinsried, Germany Product: RhCD-RAP Indication: Repair of osteochondral deficits In rabbit models of osteochondral defects, recombinant human cartilage derived retinoic acid sensitive protein (rhCD-RAP) …

    Published on 1/16/2006
  • SD Pharma preclinical data

    SD Pharmaceuticals Inc., Carlsbad, Calif. Product: SDP-014 Indication: Treat breast cancer In a mouse xenograft model of breast cancer, SDP-014 showed a dose-dependent efficacy that was equivalent or superior to …

    Published on 1/16/2006
  • CytoGenix preclinical data

    CytoGenix Inc. (CYGX), Houston, Texas Product: SynDNA smallpox vaccine Indication: Vaccinate against smallpox Researchers reported that mice treated with synDNA smallpox vaccine generated immunoglobulin and T cell …

    Published on 1/9/2006
  • ActivBiotics preclinical data

    ActivBiotics Inc., Lexingotn, Mass. Product: Rifamycin (ABI-0043) Indication: Treat Staphylococcus aureus infection In a guinea pig model of staphylococcal infections, ABI-0043 plus levofloxacin was equivalent to …

    Published on 1/2/2006
  • AntiCancer preclinical data

    AntiCancer Inc., San Diego, Calif. Product: Hair follicle stem cells Indication: Treat nerve damage In mice with severed legs, injection of hair follicle stem cells rejoined the nerves and helped regain function, …

    Published on 1/2/2006
  • Basilea Pharmaceutica AG preclinical data

    Basilea Pharmaceutica AG (SWX:BSLN), Basel, Switzerland Product: BAL4815 Indication: Candida In vitro studies showed that minimum inhibitory concentration (MIC) was lower with BAL4815 compared to variconazole (VRC) (p&…

    Published on 1/2/2006
  • Basilea Pharmaceutica AG preclinical data

    Basilea Pharmaceutica AG (SWX:BSLN), Basel, Switzerland Product: BAL8557 Indication: Treat disseminated candidiasis In a mouse model of disseminated candidiasis, treatment with BAL8557, a broad spectrum water-soluble …

    Published on 1/2/2006
  • Carrington preclinical data

    Carrington Laboratories Inc. (CARN), Irving, Texas Product: Avian H5 influenza vaccine Indication: Prevent avian influenza virus In a rat model of H5 avian influenza virus infection, intranasal delivery of H5 avian …

    Published on 1/2/2006
  • Cougar preclinical data

    Cougar Biotechnology Inc., Los Angeles, Calif. Product: Noscapine (CB3304) Indication: Treat non-Hodgkin's lymphoma In a xenograft model of NHL, daily administration of CB3304, an orally active tubulin inhibitor, …

    Published on 1/2/2006
  • Cougar preclinical data

    Cougar Biotechnology Inc., Los Angeles, Calif. Product: Noscapine (CB3304) Indication: Treat multiple myeloma (MM) In a mouse xenograft model of MM, daily administration of CB3304, an orally active tubulin inhibitor, …

    Published on 1/2/2006

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