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Chronological Index of : Preclinical Results

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  • AntriaBio preclinical data

    AntriaBio Inc. (OTCQB:ANTB), Menlo Park, Calif. Product: AB101 Business: Endocrine/Metabolic Indication: Treat Type I and II diabetes AntriaBio said a single subcutaneous dose of 37.5 mg/kg AB101 in rats and a single …

    Published on 7/13/2015
  • Bayer preclinical data

    Bayer AG (Xetra:BAYN), Leverkusen, Germany Product: BAY 1093884 Business: Hematology Indication: Treat hemophilia A In a mouse model of hemophilia A, single doses of 0.6-2 mg/kg IV BAY 1093884 given prior to induced …

    Published on 7/13/2015
  • Bind Therapeutics, AstraZeneca preclinical data

    Bind Therapeutics Inc. (NASDAQ:BIND), Cambridge, Mass. AstraZeneca plc (LSE:AZN; NYSE:AZN), London, U.K. Product: AZD2811 (formerly AZD1152-hQPA) Business: Cancer Indication: Treat solid tumors In mouse xenograft models…

    Published on 7/13/2015
  • Ciclofilin preclinical data

    Ciclofilin Pharmaceuticals Inc., San Diego, Calif. Product: CPI-431-32 Business: Infectious Indication: Treat HBV infection In a mouse model of liver fibrosis, oral CP-431-32 for 21 days reduced fibrosis by about 55% …

    Published on 7/13/2015
  • Delenex preclinical data

    Delenex Therapeutics AG, Zurich, Switzerland Product: DLX1008 Business: Cancer Indication: Treat Kaposis sarcoma In a mouse model of Kaposis sarcoma, intraperitoneal 15 mg/kg DLX1008 given 5 days per week for 3 weeks …

    Published on 7/13/2015
  • Delenex preclinical data

    Delenex Therapeutics AG, Zurich, Switzerland Product: DLX1008 Business: Cancer Indication: Treat glioma In a mouse xenograft model of glioma, DLX1008 significantly improved survival and inhibited tumor growth vs. …

    Published on 7/13/2015
  • Neuralstem preclinical data

    Neuralstem Inc. (NYSE-M:CUR), Rockville, Md. Product: HK532-IGF-1 Business: Neurology Indication: Treat Alzheimers disease (AD) In a mouse model of AD, mice transplanted with HK532-IGF-1 cells into the peri-hippocampus …

    Published on 7/13/2015
  • Nicox preclinical data

    Nicox S.A. (Euronext:COX), Sophia Antipolis, France Product: NCX 667 Business: Ophthalmic Indication: Treat glaucoma and ocular hypertension In ocular hypertensive non-human primates, 1% NCX 667 reduced intraocular …

    Published on 7/13/2015
  • Nicox preclinical data

    Nicox S.A. (Euronext:COX), Sophia Antipolis, France Product: NCX 470 Business: Ophthalmic Indication: Treat glaucoma and ocular hypertension In ocular hypertensive non-human primates, 0.042% NCX 470 significantly …

    Published on 7/13/2015
  • SciFluor preclinical data

    SciFluor Life Sciences LLC, Cambridge, Mass. Product: SF0034 Business: Neurology Indication: Treat epilepsy In rodents, SF0034 was a more potent and less toxic anticonvulsant than Trobalt retigabine. Additionally, …

    Published on 7/13/2015
  • Zealand Pharma preclinical data

    Zealand Pharma A/S (CSE:ZEAL), Glostrup, Denmark Product: ZP-DI-70 Business: Endocrine/Metabolic Indication: Treat Type II diabetes In a mouse model of obesity, subcutaneous ZP-DI-70 every 3 days for 18 days reduced …

    Published on 6/29/2015
  • Fibrocell, Intrexon preclinical data

    Fibrocell Science Inc. (NASDAQ:FCSC), Exton, Pa. Intrexon Corp. (NYSE:XON), Germantown, Md. Product: FCX-007 Business: Dermatology Indication: Treat recessive dystrophic epidermolysis bullosa (RDEB) In severe combined …

    Published on 6/15/2015
  • Applied Genetic Technologies, Pfizer preclinical data

    Applied Genetic Technologies Corp. (NASDAQ:AGTC), Alachua, Fla. Pfizer Inc. (NYSE:PFE), New York, N.Y. Product: AAV-hCNGB3 Business: Ophthalmic Indication: Treat achromatopsia In dogs with achromatopsia, AAV-hCNGB3 led …

    Published on 5/18/2015
  • Isarna Therapeutics preclinical data

    Isarna Therapeutics GmbH, Munich, Germany Product: ISTH0036 Business: Ophthalmic Indication: Treat open-angle glaucoma In a mouse model of glaucoma filtration surgery, intraocular ISTH0036 significantly improved bleb …

    Published on 5/18/2015
  • Advanced Proteome Therapeutics preclinical data

    Advanced Proteome Therapeutics Corp. (TSX-V:APC; FSE:0E8), Boston, Mass. Product: APC 101 Business: Cancer Indication: Treat breast cancer In a mouse model of breast cancer, APC 101 reduced metastases to the lungs. APC …

    Published on 5/11/2015
  • Mersana preclinical data

    Mersana Therapeutics Inc., Cambridge, Mass. Product: XMT-1522 Business: Cancer Indication: Treat HER2-positive solid tumors In mouse xenograft models of HER2-positive gastric and breast cancer, single doses of <=1 mg…

    Published on 5/11/2015
  • NGM Biopharmaceuticals preclinical data

    NGM Biopharmaceuticals Inc., South San Francisco, Calif. Product: NGM282 Business: Hepatic Indication: Treat non-alcoholic steatohepatitis (NASH) In a mouse model of NASH, NGM282 significantly reduced total body weight,…

    Published on 5/11/2015
  • Novogen, Yale University preclinical data

    Novogen Ltd. (ASX:NRT; NASDAQ:NVGN), Hornsby, Australia Yale University, New Haven, Conn. Product: Cantrixil Business: Cancer Indication: Treat ovarian cancer In a mouse model of ovarian cancer, 100 mg/kg …

    Published on 5/11/2015
  • Revive Therapeutics preclinical data

    Revive Therapeutics Ltd. (TSX-V:RVV), Vaughan, Ontario Product: Tianeptine (REV-003) Business: Neurology Indication: Treat Rett syndrome In a mouse model of Rett syndrome, REV-003 improved motor coordination and gait …

    Published on 5/11/2015
  • Tamir preclinical data

    Tamir Biotechnology Inc., San Diego, Calif. Product: TMR004 Business: Infectious Indication: Treat Ebola virus infection In mice infected with Ebola virus, intraperitoneal TMR004 led to a survival rate of 70-80% vs. 0% …

    Published on 5/11/2015
  • Blueprint Medicines preclinical data

    Blueprint Medicines Corp., Cambridge, Mass. Product: BLU-285 Business: Cancer Indication: Treat gastrointestinal stromal tumors (GIST) In a mouse model of treatment-refractory GIST, once-daily 30 and 100 mg/kg oral BLU-…

    Published on 4/27/2015
  • Momenta Pharmaceuticals Inc, Novartis preclinical data

    Momenta Pharmaceuticals Inc. (NASDAQ:MNTA), Cambridge, Mass. Novartis AG (NYSE:NVS; SIX:NOVN), Basel, Switzerland Product: Glatiramer acetate (Glatopa) (M356) Business: Autoimmune Indication: Treat relapsing forms of …

    Published on 4/27/2015
  • PhaseBio preclinical data

    PhaseBio Pharmaceuticals Inc., Malvern, Pa. Product: Vasomera (PB1046) Business: Musculoskeletal Indication: Treat Duchenne muscular dystrophy (DMD) In a mouse model of DMD, thrice-weekly 1.5 mg/kg subcutaneous PB1046 …

    Published on 4/27/2015
  • BioInvent International A preclinical data

    BioInvent International AB (SSE:BINV), Lund, Sweden Product: BI-1206 Business: Cancer Indication: Treat lymphoma In mice, BI-1206 prevented tumor cell internalization of Rituxan rituximab, a chimeric mAb against CD20 …

    Published on 4/20/2015
  • AstraZeneca pl preclinical data

    AstraZeneca plc (LSE:AZN; NYSE:AZN), London, U.K. Product: Saracatinib (AZD0530) Business: Neurology Indication: Treat Alzheimers disease (AD) In a mouse model of AD, saracatinib for 4 weeks led to complete reversal of …

    Published on 4/13/2015

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