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Chronological Index of : Preclinical Results

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  • Addex preclinical data

    Addex Therapeutics Ltd. (SIX:ADXN), Geneva, Switzerland Product: Dipraglurant-IR (ADX48621) Business: Neurology Indication: Treat non-motor symptoms in patients with Parkinsons disease (PD) In mice, 50 mg/kg oral …

    Published on 8/24/2015
  • Aeolus preclinical data

    Aeolus Pharmaceuticals Inc. (OTCQB:AOLS), Mission Viejo, Calif. Product: Manganese porphyrin (AEOL 10150) Business: Neurology Indication: Treat epilepsy In a rat model of epilepsy, AEOL 10150 improved spatial memory …

    Published on 8/24/2015
  • Chimerix preclinical data

    Chimerix Inc. (NASDAQ:CMRX), Durham, N.C. Product: Brincidofovir (CMX001) Business: Infectious Indication: Prevent smallpox infection In rabbits infected with the lethal rabbitpox virus, brincidofovir given 24 or 48 …

    Published on 8/24/2015
  • Chrysalis BioTherapeutics preclinical data

    Chrysalis BioTherapeutics Inc., Galveston, Texas Product: Rusalatide acetate (Chrysalin) (TP508) Business: Other Indication: Treat acute radiation syndrome (ARS) In mice, a single injection of TP508 given 24 hours after…

    Published on 8/24/2015
  • Inovio preclinical data

    Inovio Pharmaceuticals Inc. (NASDAQ:INO), Blue Bell, Pa. Product: DNA-based mAb targeting dengue virus Business: Infectious Indication: Prevent dengue virus infection In mice challenged with a lethal dose of dengue …

    Published on 8/24/2015
  • Intrexon, Oragenics preclinical data

    Intrexon Corp. (NYSE:XON), Germantown, Md. Oragenics Inc. (NYSE-M:OGEN), Alachua, Fla. Product: Mutacin 1140 (MU1140) Business: Infectious Indication: Treat Clostridium difficile infection (CDI) In rodents infected with…

    Published on 8/24/2015
  • Kadimastem preclinical data

    Kadimastem Ltd. (Tel Aviv:KDST), Ness Ziona, Israel Product: Human embryonic stem cell (hESC)-derived astrocyte precursor cells Business: Neurology Indication: Treat amyotrophic lateral sclerosis (ALS) In a rat model of…

    Published on 8/24/2015
  • Ramsey Lake Pharma preclinical data

    Ramsey Lake Pharma Corp., Sudbury, Ontario Product: VR23 Business: Cancer Indication: Treat multiple myeloma (MM) In non-resistant MM cell lines, VR23 plus Velcade bortezomib reduced cancer cell growth to 1.6% vs. 12.5%…

    Published on 8/24/2015
  • AntriaBio preclinical data

    AntriaBio Inc. (OTCQB:ANTB), Menlo Park, Calif. Product: AB101 Business: Endocrine/Metabolic Indication: Treat Type I and II diabetes AntriaBio said a single subcutaneous dose of 37.5 mg/kg AB101 in rats and a single …

    Published on 7/13/2015
  • Bayer preclinical data

    Bayer AG (Xetra:BAYN), Leverkusen, Germany Product: BAY 1093884 Business: Hematology Indication: Treat hemophilia A In a mouse model of hemophilia A, single doses of 0.6-2 mg/kg IV BAY 1093884 given prior to induced …

    Published on 7/13/2015
  • Bind Therapeutics, AstraZeneca preclinical data

    Bind Therapeutics Inc. (NASDAQ:BIND), Cambridge, Mass. AstraZeneca plc (LSE:AZN; NYSE:AZN), London, U.K. Product: AZD2811 (formerly AZD1152-hQPA) Business: Cancer Indication: Treat solid tumors In mouse xenograft models…

    Published on 7/13/2015
  • Ciclofilin preclinical data

    Ciclofilin Pharmaceuticals Inc., San Diego, Calif. Product: CPI-431-32 Business: Infectious Indication: Treat HBV infection In a mouse model of liver fibrosis, oral CP-431-32 for 21 days reduced fibrosis by about 55% …

    Published on 7/13/2015
  • Delenex preclinical data

    Delenex Therapeutics AG, Zurich, Switzerland Product: DLX1008 Business: Cancer Indication: Treat Kaposis sarcoma In a mouse model of Kaposis sarcoma, intraperitoneal 15 mg/kg DLX1008 given 5 days per week for 3 weeks …

    Published on 7/13/2015
  • Delenex preclinical data

    Delenex Therapeutics AG, Zurich, Switzerland Product: DLX1008 Business: Cancer Indication: Treat glioma In a mouse xenograft model of glioma, DLX1008 significantly improved survival and inhibited tumor growth vs. …

    Published on 7/13/2015
  • Neuralstem preclinical data

    Neuralstem Inc. (NYSE-M:CUR), Rockville, Md. Product: HK532-IGF-1 Business: Neurology Indication: Treat Alzheimers disease (AD) In a mouse model of AD, mice transplanted with HK532-IGF-1 cells into the peri-hippocampus …

    Published on 7/13/2015
  • Nicox preclinical data

    Nicox S.A. (Euronext:COX), Sophia Antipolis, France Product: NCX 667 Business: Ophthalmic Indication: Treat glaucoma and ocular hypertension In ocular hypertensive non-human primates, 1% NCX 667 reduced intraocular …

    Published on 7/13/2015
  • Nicox preclinical data

    Nicox S.A. (Euronext:COX), Sophia Antipolis, France Product: NCX 470 Business: Ophthalmic Indication: Treat glaucoma and ocular hypertension In ocular hypertensive non-human primates, 0.042% NCX 470 significantly …

    Published on 7/13/2015
  • SciFluor preclinical data

    SciFluor Life Sciences LLC, Cambridge, Mass. Product: SF0034 Business: Neurology Indication: Treat epilepsy In rodents, SF0034 was a more potent and less toxic anticonvulsant than Trobalt retigabine. Additionally, …

    Published on 7/13/2015
  • Zealand Pharma preclinical data

    Zealand Pharma A/S (CSE:ZEAL), Glostrup, Denmark Product: ZP-DI-70 Business: Endocrine/Metabolic Indication: Treat Type II diabetes In a mouse model of obesity, subcutaneous ZP-DI-70 every 3 days for 18 days reduced …

    Published on 6/29/2015
  • Fibrocell, Intrexon preclinical data

    Fibrocell Science Inc. (NASDAQ:FCSC), Exton, Pa. Intrexon Corp. (NYSE:XON), Germantown, Md. Product: FCX-007 Business: Dermatology Indication: Treat recessive dystrophic epidermolysis bullosa (RDEB) In severe combined …

    Published on 6/15/2015
  • Applied Genetic Technologies, Pfizer preclinical data

    Applied Genetic Technologies Corp. (NASDAQ:AGTC), Alachua, Fla. Pfizer Inc. (NYSE:PFE), New York, N.Y. Product: AAV-hCNGB3 Business: Ophthalmic Indication: Treat achromatopsia In dogs with achromatopsia, AAV-hCNGB3 led …

    Published on 5/18/2015
  • Isarna Therapeutics preclinical data

    Isarna Therapeutics GmbH, Munich, Germany Product: ISTH0036 Business: Ophthalmic Indication: Treat open-angle glaucoma In a mouse model of glaucoma filtration surgery, intraocular ISTH0036 significantly improved bleb …

    Published on 5/18/2015
  • Advanced Proteome Therapeutics preclinical data

    Advanced Proteome Therapeutics Corp. (TSX-V:APC; FSE:0E8), Boston, Mass. Product: APC 101 Business: Cancer Indication: Treat breast cancer In a mouse model of breast cancer, APC 101 reduced metastases to the lungs. APC …

    Published on 5/11/2015
  • Mersana preclinical data

    Mersana Therapeutics Inc., Cambridge, Mass. Product: XMT-1522 Business: Cancer Indication: Treat HER2-positive solid tumors In mouse xenograft models of HER2-positive gastric and breast cancer, single doses of <=1 mg…

    Published on 5/11/2015
  • NGM Biopharmaceuticals preclinical data

    NGM Biopharmaceuticals Inc., South San Francisco, Calif. Product: NGM282 Business: Hepatic Indication: Treat non-alcoholic steatohepatitis (NASH) In a mouse model of NASH, NGM282 significantly reduced total body weight,…

    Published on 5/11/2015

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