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Chronological Index of : Preclinical Results

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  • BioLineRx, JHL Biotech preclinical data

    BioLineRx Ltd.(Tel Aviv:BLRX; NASDAQ:BLRX), Jerusalem, Israel JHL Biotech Inc., Zhubei, Taiwan Product: BL-9020 Business: Endocrine/Metabolic Indication: Treat Type I diabetes In a mouse model of diabetes, short-term …

    Published on 3/16/2015
  • BrainStorm preclinical data

    BrainStorm Cell Therapeutics Inc. (NASDAQ:BCLI), New York, N.Y. Product: NurOwn (MSC-NTF cells) (formerly Neurotrophic Factor Cells) Business: Neurology Indication: Treat autism In a mouse model of autism, a single …

    Published on 2/9/2015
  • arGEN-X preclinical data

    arGEN-X N.V. (Euronext:ARGX), Breda, the Netherlands Product: ARGX-110 Business: Cancer Indication: Treat chronic myelogenous leukemia (CML) In a mouse model of CML, a murine formulation of 300 g intraperitoneal ARGX-…

    Published on 1/19/2015
  • Epizyme, GlaxoSmithKline preclinical data

    Epizyme Inc. (NASDAQ:EPZM), Cambridge, Mass. GlaxoSmithKline plc (LSE:GSK; NYSE:GSK), London, U.K. Product: EPZ015666 Business: Cancer Indication: Treat mantle cell lymphoma (MCL) In mouse xenograft models of MCL, twice…

    Published on 1/19/2015
  • Global Blood Therapeutics preclinical data

    Global Blood Therapeutics Inc., South San Francisco, Calif. Product: GBT440 (formerly GTx011) Business: Hematology Indication: Treat sickle cell disease In a mouse model of sickle cell disease, twice-daily 100 mg/kg …

    Published on 1/12/2015
  • Pharnext preclinical data

    Pharnext S.A.S., Issy-Les-Moulineaux, France Product: PXT-864 Business: Neurology Indication: Treat Alzheimers disease (AD) In rodent models of AD, PXT-864 led to significant alleviation of induced cognitive deficits in…

    Published on 1/12/2015
  • Angiochem preclinical data

    Angiochem Inc., Montreal, Quebec Product: ANG4043 Business: Cancer Indication: Treat HER2-positive brain cancer In mice bearing intracranial HER2-positive tumors, twice-weekly 15 mg/kg IV ANG4043 significantly improved …

    Published on 12/15/2014
  • Glythera preclinical data

    Glythera Ltd., Newcastle upon Tyne, U.K. Product: PermaLink Business: Cancer Indication: Treat cancer In a mouse xenograft model of cancer, an antibody-drug conjugate (ADC) containing Glythera's PermaLink linker led to …

    Published on 11/3/2014
  • Novavax preclinical data

    Novavax Inc. (NASDAQ:NVAX), Gaithersburg, Md. Product: EBOV GP vaccine Business: Infectious Indication: Prevent Ebola virus infection In mice, 5 Ug EBOV GP vaccine given at baseline and day 14 led to antibody titers …

    Published on 11/3/2014
  • Peregrine preclinical data

    Peregrine Pharmaceuticals Inc. (NASDAQ:PPHM), Tustin, Calif. Product: Bavituximab (3G4) Business: Infectious Indication: Treat Ebola virus infection In vitro data showed that bavituximab specifically binds to cells …

    Published on 10/20/2014
  • Chimerix preclinical data

    Chimerix Inc. (NASDAQ:CMRX), Durham, N.C. Product: Brincidofovir (CMX001) Business: Infectious Indication: Treat Ebola virus infection Chimerix said in vitro data from studies conducted at the CDC and NIH showed that …

    Published on 10/13/2014
  • Aeolus preclinical data

    Aeolus Pharmaceuticals Inc. (OTCQB:AOLS), Mission Viejo, Calif. Product: Manganese porphyrin (AEOL 10150) Business: Other Indication: Treat acute radiation syndrome (ARS) In non-human primates, AEOL 10150 given for 60 …

    Published on 10/6/2014
  • Alnylam preclinical data

    Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Cambridge, Mass. Product: ALN-AGT Business: Genitourinary Indication: Treat preeclampsia In a rat model of preeclampsia, subcutaneous ALN-AGT led to >90% knockdown of …

    Published on 10/6/2014
  • Novan preclinical data

    Novan Inc., Durham, N.C. Product: SB206 Business: Infectious Indication: Treat HPV infection In a rabbit model of HPV infection, topical SB206 led to complete inhibition of papilloma growth. Data were presented at the …

    Published on 9/29/2014
  • arGEN-X preclinical data

    arGEN-X N.V. (Euronext:ARGX), Breda, the Netherlands Product: ARGX-113 Business: Autoimmune Indication: Treat autoimmune diseases In non-human primates, repeat doses of ARGX-113 led to rapid and transient depletion of …

    Published on 9/22/2014
  • Hera Therapeutics preclinical data

    Hera Therapeutics Inc., Del Mar, Calif. Product: HTI-1968 Business: Infectious Indication: Treat HPV infection In cultured human cell models, HTI-1968 blocked the replication of HPV types 11, 16, and 18 cells. Data were…

    Published on 9/22/2014
  • Seek Ltd., ValiRx preclinical data

    Seek Ltd., London, U.K. ValiRx plc (LSE:VAL), London, U.K. Product: VAL401 Business: Cancer Indication: Treat non-small cell lung cancer (NSCLC) In an in vivo model of NSCLC, VAL401 for 6 weeks led to at least a 50% …

    Published on 9/22/2014
  • Soligenix preclinical data

    Soligenix Inc. (OTCBB:SNGX), Princeton, N.J. Product: RiVax, Ricin Toxin Vaccine Business: Other Indication: Vaccinate against ricin toxin In non-human primates, RiVax significantly improved survival against exposure to…

    Published on 9/22/2014
  • Chimerix preclinical data

    Chimerix Inc. (NASDAQ:CMRX), Durham, N.C. Product: Brincidofovir (CMX001) Business: Infectious Indication: Treat adenovirus infection Chimerix reported data at the Interscience Conference on Antimicrobial Agents and …

    Published on 9/15/2014
  • CrystalGenomics preclinical data

    CrystalGenomics Inc. (KOSDAQ:083790), Seongnam, South Korea Product: Polmacoxib (formerly CG100649) Business: Cancer Indication: Treat and prevent colorectal cancer In a premalignant mouse prevention study, polmacoxib …

    Published on 9/15/2014
  • Defyrus, Mapp Biopharmaceutical preclinical data

    Defyrus Inc., Toronto, Ontario Mapp Biopharmaceutical Inc., San Diego, Calif. Product: ZMapp Business: Infectious Indication: Treat Ebola infection In 18 rhesus monkeys, ZMapp initiated 3-5 days post-infection led to a …

    Published on 9/1/2014
  • Immunovaccine preclinical data

    Immunovaccine Inc. (TSX-V:IMV), Halifax, Nova Scotia Product: DepoVax-formulated Ebola vaccine Business: Infectious Indication: Vaccinate against Ebola infection In 4 cynomolgus monkeys, 2 doses of ImmunoVaccines …

    Published on 9/1/2014
  • Addex preclinical data

    Addex Therapeutics Ltd. (SIX:ADXN), Geneva, Switzerland Product: ADX71441 Business: Neurology Indication: Treat nicotine addiction In nicotine-dependent mice, 1, 3 and 10 mg/kg oral ADX71441 administered 60 minutes …

    Published on 8/11/2014
  • Vertex preclinical data

    Vertex Pharmaceuticals Inc. (NASDAQ:VRTX), Boston, Mass. Product: Lumacaftor (VX-809) Business: Pulmonary Indication: Treat cystic fibrosis (CF) Data from a pair of in vitro studies published in Science Translational …

    Published on 7/28/2014
  • ImStem Biotechnology preclinical data

    ImStem Biotechnology Inc., Farmington, Conn. Product: HES-MSCs Business: Autoimmune Indication: Treat multiple sclerosis (MS) In an animal model of MS, human embryonic stem cell-derived mesenchymal stem cells (hES-MSCs)…

    Published on 7/21/2014

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