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Chronological Index of : Preclinical Results

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  • SRF231: Preclinical data

    In a mouse xenograft model of lymphoma, SRF231 plus Rituxan rituximab led to a greater reduction in tumor volume vs. Rituxan alone. Data were presented at the Society for Immunotherapy of Cancer meeting in National …

    Published on 11/21/2016
  • SPX-101: Preclinical data

    In a mouse model of CF, SPX-101 significantly improved survival at day 14 vs. vehicle-treated controls (p=0.04). SPX-101 also significantly improved mucociliary clearance vs. controls (p<0.05). Data were presented at…

    Published on 11/14/2016
  • ZIKV-117: Preclinical data

    In pregnant mice infected with Zika virus, ZIKV-117 given either before or after infection reduced Zika virus levels in the blood and brain tissues of the mother and in the placenta and fetal brain compared to untreated…

    Published on 11/14/2016
  • Gilead preclinical data

    Gilead Sciences Inc. (NASDAQ:GILD), Foster City, Calif. Product: ND-646 Business: Cancer Indication: Treat non-small cell lung cancer (NSCLC) In a mouse xenograft model of NSCLC, twice-daily 50 and 100 mg/kg oral ND-646…

    Published on 10/24/2016
  • BioCryst preclinical data

    BioCryst Pharmaceuticals Inc. (NASDAQ:BCRX), Durham, N.C. Product: BCX4430 Business: Infectious Indication: Treat Ebola virus infection In rhesus macaques infected with Ebola virus, twice-daily 100 mg/kg intramuscular …

    Published on 10/10/2016
  • Neuralstem preclinical data

    Neuralstem Inc. (NASDAQ:CUR), Rockville, Md. Product: NSI-189 Business: Neurology Indication: Treat and prevent diabetic neuropathy In mouse models of diabetes, once-daily NSI-189 significantly protected nerve function …

    Published on 10/10/2016
  • Siamab Therapeutics preclinical data

    Siamab Therapeutics Inc., Cambridge, Mass. Product: ST1 antibody-drug conjugate (ADC) Business: Cancer Indication: Treat ovarian cancer In a mouse xenograft model of ovarian cancer, Siamabs ST1 ADC composed of a …

    Published on 10/10/2016
  • Omeros preclinical data

    Omeros Corp. (NASDAQ:OMER), Seattle, Wash. Product: OMS906 Business: Autoimmune Indication: Treat arthritis In an animal model of arthritis, OMS906 significantly reduced the incidence and severity of arthritis by 86% …

    Published on 9/5/2016
  • Omeros preclinical data

    Omeros Corp. (NASDAQ:OMER), Seattle, Wash. Product: OMS906 Business: Hematology Indication: Treat paroxysmal nocturnal hemoglobinuria (PNH) In an animal model of PNH, 80% destruction of PNH-like red blood cells was …

    Published on 9/5/2016
  • VBI Vaccines preclinical data

    VBI Vaccines Inc. (NASDAQ:VBIV; TSX:VBV), Cambridge, Mass. Product: VBI-1901 Business: Cancer Indication: Treat cytomegalovirus (CMV)-positive glioblastoma multiforme (GBM) In an ex vivo model of CMV-positive GBM, VBI-…

    Published on 9/5/2016
  • Aethlon Medical preclinical data

    Aethlon Medical Inc. (NASDAQ:AEMD), San Diego, Calif. Product: Aethlon Hemopurifier Business: Infectious Indication: Treat Zika virus infection In vitro, the Aethlon Hemopurifier led to 95% clearance of Zika virus from …

    Published on 8/22/2016
  • Ligand, Viking Therapeutics preclinical data

    Ligand Pharmaceuticals Inc. (NASDAQ:LGND), La Jolla, Calif. Viking Therapeutics Inc. (NASDAQ:VKTX), San Diego, Calif. Product: VK0214 (formerly LG0956965) Business: Neurology Indication: Treat X-linked …

    Published on 8/22/2016
  • Fate Therapeutics preclinical data

    Fate Therapeutics Inc. (NASDAQ:FATE), San Diego, Calif. Product: ToleraCyte Business: Endocrine/Metabolic Indication: Treat Type I diabetes In pre-hyperglycemic non-obese diabetic mice, a single dose of ToleraCyte …

    Published on 6/27/2016
  • Basilea preclinical data

    Basilea Pharmaceutica AG (SIX:BSLN), Basel, Switzerland Product: BAL101553 Business: Cancer Indication: Treat breast cancer In mouse xenograft models of chemo-sensitive and chemo-refractory breast cancer, IV BAL101553 …

    Published on 4/28/2014
  • Isomerase Therapeutics, NeuroVive preclinical data

    Isomerase Therapeutics Ltd., Cambridge, U.K. NeuroVive Pharmaceutical AB (SSE:NVP), Lund, Sweden Product: NVP018 (formerly BC556) Business: Infectious Indication: Treat HBV infection In a mouse model of HBV infection, …

    Published on 4/28/2014
  • Idenix preclinical data

    Idenix Pharmaceuticals Inc. (NASDAQ:IDIX), Cambridge, Mass. Product: IDX21437 Business: Infectious Indication: Treat HCV infection In HCV cell-based assays, IDX21437 selectively inhibited HCV replicons. Idenix also said…

    Published on 4/7/2014
  • Isis Pharmaceuticals preclinical data

    Isis Pharmaceuticals Inc. (NASDAQ:ISIS), Carlsbad, Calif. Product: ISIS-HBVRx (formerly ISIS-GSK3Rx) Business: Infectious Indication: Treat HBV infection In a mouse model of HBV infection, subcutaneous doses of >=11 …

    Published on 4/7/2014
  • Patrys preclinical data

    Patrys Ltd. (ASX:PAB), Melbourne, Australia Product: PAT-LM1 Business: Cancer Indication: Treat lymphoma In vitro, PAT-LM1 induced cell death in mantle cell lymphoma (MCL) and histiocytic lymphoma cells. Patrys declined…

    Published on 4/7/2014
  • Novogen preclinical data

    Novogen Ltd. (ASX:NRT; NASDAQ:NVGN), Hornsby, Australia Product: Trilexium (Trx-1) Business: Cancer Indication: Treat ovarian cancer In a mouse xenograft model of ovarian cancer, Trx-1 significantly reduced tumor growth…

    Published on 3/31/2014
  • Synta preclinical data

    Synta Pharmaceuticals Corp. (NASDAQ:SNTA), Lexington, Mass. Product: HDC docetaxel (STA-9183) Business: Cancer Indication: Treat solid tumors In mouse xenograft models of triple-negative breast cancer (TNBC) and non-…

    Published on 3/10/2014
  • Synta preclinical data

    Synta Pharmaceuticals Corp. (NASDAQ:SNTA), Lexington, Mass. Product: HDC SN-38 (STA-12-8666) Business: Cancer Indication: Treat solid tumors In mouse xenograft tumor models, STA-12-8666 safely delivered >10 times …

    Published on 3/10/2014
  • Angiochem preclinical data

    Angiochem Inc., Montreal, Quebec Product: ANG2002 Business: Neurology Indication: Treat pain In rat models of neuropathic and bone cancer pain, 0.05 mg/kg ANG2002 significantly reduced pain behaviors vs. vehicle-treated…

    Published on 3/3/2014
  • AngioGenex preclinical data

    AngioGenex Inc. (Pink:AGGX), New York, N.Y. Product: Idantirx (AGX-51) Business: Cancer Indication: Treat cancer In a mouse model of breast cancer, twice-daily AGX-51 significantly blocked tumor growth at a dose <7 …

    Published on 3/3/2014
  • Biokine, BioLineRx preclinical data

    Biokine Therapeutics Ltd., Tel Aviv, Israel BioLineRx Ltd. (Tel Aviv:BLRX; NASDAQ:BLRX), Jerusalem, Israel Product: BL-8040 (formerly BKT-140) Business: Cancer Indication: Treat chronic myelogenous leukemia (CML) In …

    Published on 3/3/2014
  • Epizyme, Eisai preclinical data

    Epizyme Inc. (NASDAQ:EPZM), Cambridge, Mass. Eisai Co. Ltd. (Tokyo:4523), Tokyo, Japan Product: EPZ-6438, E7438 Business: Cancer Indication: Treat non-Hodgkin's lymphoma (NHL) In a mouse xenograft model of enhancer of …

    Published on 3/3/2014

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