-
Harvard Medical School researchers have shown that noninvasive detection of a key metabolite in the brain can diagnose IDH1-mutant tumors. Agios plans to use the method for the preclinical development of its glioma …
Published on 2/2/2012
-
Max Planck cell biologists are challenging the research community to abandon the HeLa cell line in favor of stem cell lines. Although the latter may provide better in vitro disease models, technical and economic …
Published on 1/26/2012
-
Brazilian and U.S. researchers have engineered a prototype cancer immunotherapy consisting of an attenuated strain of Trypanosoma cruzi expressing a cancer antigen that stimulates a potent response in mice. The team is …
Published on 1/12/2012
-
NCI and University of Tokyo researchers have developed a fluorescent probe that can be sprayed onto tissue during surgery to detect small metastases. The researchers plan to validate the method in fresh surgical tissue …
Published on 1/5/2012
-
A Stanford team has developed a computational pathology system called C-Path that provides more accurate prognostic scores of breast cancer tissue than classical pathology. The next steps will be modifying the method to…
Published on 12/15/2011
-
Dana-Farber researchers have developed an in vitro assay that predicts patient response to chemotherapy by directly measuring whether a cell is prone to apoptosis. Eutropics has exclusively licensed the assay and is …
Published on 12/15/2011
-
A Memorial Sloan-Kettering team has honed a protocol for producing large quantities of human dopaminergic neurons that could be grafted into patients with PD or used as a screening platform for the disease. Scaling up …
Published on 12/1/2011
-
Putting pluripotent pieces together Figure 1. From fibroblast to functional hepatocyte. Fibroblasts from individuals with mutant a1-antitrypsin (AAT; A1AT; SERPINA1) are transformed into induced pluripotent stem (iPS…
Published on 11/3/2011
-
An international team has developed a method for genetically altering induced pluripotent stem cells that could be useful for treating inherited diseases. The team now plans to scale up the method but will need to show …
Published on 11/3/2011
-
U.K. researchers are designing a trial at the University of Cambridge to verify the validity and utility of a prognostic gene expression signature in CD8+ T cells to guide treatment decisions for inflammatory bowel …
Published on 10/27/2011
-
U.S. researchers have engineered mice that model the mechanisms of three relatively common genetic causes of autism spectrum disorder, making it possible to undertake phenotypic screening for therapeutics. Behavioral …
Published on 10/20/2011
-
U.S. researchers have compared mouse proteomes to identify plasma protein signatures that could be mined for biomarkers to aid the detection of lung cancer. The signatures may lead to a noninvasive follow-up test to …
Published on 10/6/2011
-
Tissue factor-activated prodrugs Figure 1. Tissue factor-activated coagulation cascade. The tissue factor (TF)-induced coagulation cascade is constantly activated in the tumor microenvironment because TF is …
Published on 9/29/2011
-
A Scripps team has designed a way to activate chemotherapy prodrugs in the tumor microenvironment. The team's doxorubicin prodrugs, which have been licensed to Affinity Pharmaceuticals, showed better efficacy and safety…
Published on 9/29/2011
-
The organization Aeras is working with Albert Einstein College of Medicine researchers to develop a tuberculosis vaccine employing a vector the medical school team has used to produce large decreases in bacterial burden…
Published on 9/22/2011
-
Rockefeller University researchers have developed an antibody-engineering technique that increases the potency of antitumor mAbs. The method involves switching Fc gamma-receptor IIb from an inhibitor to a stimulator of …
Published on 9/15/2011
-
A UCSB team believes topical formulations of siRNA will be possible using a peptide carrier that can transport siRNA through the skin. The researchers plan to test such conjugates in animal models of dermatological …
Published on 9/15/2011
-
University of Illinois researchers have developed DNA sensors that can be used with personal glucose meter technology for fast and inexpensive detection and quantification of nonglucose targets in a sample. The approach…
Published on 9/8/2011
-
Stanford researchers have developed an approach for separating human pluripotent stem cells from teratoma-forming cells. The antibody-based process needs to be refined to insure that all tumor-forming cells can be …
Published on 8/25/2011
-
Metabolically, man or mouse? Figure 1. Human ectopic artificial liver mouse. Primary human hepatocytes are cocultivated with stabilizing stromal mouse fibroblasts on collagen-coated plates for 7-10 days. They are …
Published on 8/4/2011
-
Massachusetts researchers have created mice bearing human ectopic artificial livers. The animals are healthy and immunocompetent, which should give more consistent results when testing for drug metabolism, drug-drug …
Published on 8/4/2011
-
Tools: Dynamic detox Figure 1. Immunochemically dynamic vaccine. The heroin molecule itself is too small to elicit an immune response. Thus, a team from The Scripps Research Institute attached the molecule to a …
Published on 7/28/2011
-
A Scripps team has created a heroin vaccine that displays multiple drug-like antigens and leads to robust antibody titers that block the effects of heroin in rats. Unlike current options for preventing heroin addiction,…
Published on 7/28/2011
-
University of Miami researchers have found that FGF23 could help predict whether a patient with early stages of kidney disease is at risk of progressing to and dying from ESRD. However, other researchers are not yet …
Published on 7/21/2011
-
U.K. researchers have shown that priming epicardial progenitor cells with RegeneRx's thymosin beta4 peptide could promote the generation of mature cardiomyocytes after myocardial infarction. The findings point to an …
Published on 7/21/2011