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  • Cyclotide synthesis

    Tools: Circling back to basics Box 1. Cyclotide synthesis. Although synthetic macrocycle chemistry has been inspired by the study of natural products such as cyclosporine, the biosynthetic pathways for many …

    Published on 8/21/2014
  • Circling back to basics

    Creating potent and orally bioavailable macrocycles is more challenging than developing small molecules, but a trio of studies could close the gap by proposing new design guidelines, identifying protein-protein …

    Published on 8/21/2014
  • Figure 1: Liver preservation protocol

    Tools: Liver, supercooled Figure 1. Liver preservation protocol. The liver preservation protocol reported by Berendsen et al. combined subnormothermic machine perfusion (SNMP) with supercooling and enabled rat livers…

    Published on 8/14/2014
  • Liver, supercooled

    Harvard Medical School scientists have reported a method that triples the time rat livers can be preserved for transplant and could thus increase the number of donor organs available for patients. Spinout Organ …

    Published on 8/14/2014
  • Box 1: Specific BETs on remyelination

    Tools: High throughput remyelination Box 1. Specific BETs on remyelination A team at the Icahn School of Medicine at Mount Sinai has linked BET bromodomain protein-regulated gene transcription to oligodendrocyte …

    Published on 8/7/2014
  • Getting personal with CTCs

    Johnson & Johnson has licensed a technology that could personalize cancer treatment by using circulating tumor cells to screen for drug susceptibility and tumor mutations that evolve over time. But converting the method…

    Published on 8/7/2014
  • High throughput remyelination

    Remyelinating compounds have been difficult to identify in part because of a dearth of suitable high throughput screening platforms. UCSF researchers have now developed an assay that can identify active compounds and …

    Published on 8/7/2014
  • Regenerative light touch

    A Harvard University team has shown that low-power laser treatment could be used to noninvasively drive dental stem cell differentiation and tissue regeneration in rats. What remains to be determined is whether the …

    Published on 7/10/2014
  • A big heart

    Cell therapies in the clinic for heart failure draw from divergent sources of nonembryonic stem cells but collectively have shown minimal improvements in cardiac function. A University of Washington team thinks human …

    Published on 5/22/2014
  • Blood test for asthma

    Salus has licensed a technology that it thinks can improve asthma diagnosis using a microfluidic device that analyzes the mobility of inflammatory cells contained in a single drop of blood.

    Published on 5/15/2014
  • Zapping hearing loss

    An Australian team has devised a method for treating hearing loss by delivering gene therapy to the inner ear. The technique uses electric fields generated by an implantable device to electroporate a transgene into …

    Published on 5/8/2014
  • Figure 1: Gene therapy by cochlear implant

    Tools: Zapping hearing loss Figure 1. Gene therapy by cochlear implant. Cochlear implants are multielectrode arrays that treat severe forms of hearing loss caused by the absence of mechanosensory hair cells. Pinyon …

    Published on 5/8/2014
  • Superhuman mice

    The paradox of current mouse-based antibody platforms is that the Ig gene manipulations used to generate the mice can limit the animals' ability to produce robust antibody responses. Kymab and Regeneron have now …

    Published on 5/1/2014
  • Toxic assets

    A tool for in vivo detection of liver toxicity could represent a substantial improvement over in vitro methods. The litmus test for the Stanford University inventors will be to show that the nanoparticle-based method …

    Published on 4/10/2014
  • Figure 1: Bird's-eye view of IgG hexamers

    Tools: Complementing mAbs Figure 1. Bird's-eye view of IgG hexamers. The complement component 1 q subcomponent (C1q) complex has six antibody-binding headpieces (blue circles) and activates the complement system. …

    Published on 4/3/2014
  • Complementing mAbs

    Genmab and Utrecht University researchers have shown that hexameric IgG complexes can activate the complement cascade. Genmab is now selecting key mutations and antibody candidates to generate IgG antibodies that …

    Published on 4/3/2014
  • Plasma lipids: harbingers of AD?

    A team of U.S. researchers has shown that a panel of plasma lipid markers could predict Alzheimer's disease. The panel could enrich clinical trials testing disease-modifying therapies, but validation studies must first …

    Published on 3/20/2014
  • Hitchhiker's guide to the lymph node

    An MIT team has provided a recipe for delivering cancer vaccines to lymph nodes by tethering them to albumin. In proof-of-concept studies in mice, lymph node-targeted tumor antigens and adjuvants elicited strong immune …

    Published on 3/13/2014
  • Taking TIMP3 to heart

    A U.S. team has leveraged the cardioprotective activity of TIMP3 using a formulation and delivery strategy that avoids off-target effects. Preclinical data indicate that the procedure could help prevent heart failure …

    Published on 3/6/2014
  • (Pluri)potent acid

    Researchers have generated pluripotent mouse stem cells by simply exposing somatic cells to low pH. If other researchers can replicate it - something they have thus far failed to do - the minimally invasive technique …

    Published on 2/27/2014
  • Figure 1: Ubiquibodies

    Tools: Degradation from within Figure 1. Ubiquibodies. Portnoff et al. have demonstrated a strategy for targeted destruction of intracellular proteins using engineered intracellular antibodies that deliver ubiquitin …

    Published on 2/20/2014
  • Degradation from within

    A Cornell group has proof of concept for proteasomal degradation of intracellular proteins using designer binding proteins to deliver ubiquitin to their targets. The challenge for Ubiquizyme, a newco formed around this …

    Published on 2/20/2014
  • Micromanaging the microenvironment

    A Massachusetts team has designed an in vivo shRNA screen to discover tumor targets that can improve the efficacy of T cell immunotherapies. The system showed that current checkpoint inhibitors barely scratch the …

    Published on 2/13/2014
  • Figure 1: In vivo shRNA discovery of immunotherapy targets

    Tools: Micromanaging the microenvironment Figure 1. In vivo shRNA discovery of immunotherapy targets. T cells infected with shRNA libraries were injected into mice with melanoma. Several days later, T cells were …

    Published on 2/13/2014
  • RNA is for activation

    Although siRNAs have been validated as therapeutics to knock down gene expression, short double-stranded RNAs can also turn on gene expression. An academic team sponsored by MiNA Therapeutics has attacked liver cancer …

    Published on 2/6/2014

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