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SciBX: Science-Business eXchange
As published Thursday, September 11, 2014

  • Cover Story: Kinase convergence on eIF4F

    By Kai-Jye Lou, Senior Writer

    Kinase convergence on eIF4F

    Researchers in France have shown that resistance to BRAF and MEK inhibitors in melanoma and possibly other cancers can be driven by pathways that converge on the eukaryotic translation initiation factor 4F complex.1 The findings suggest developing inhibitors of the complex in combination with marketed kinase inhibitor drugs could help circumvent resistance.

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