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SciBX: Science-Business eXchange
As published Thursday, August 21, 2014


  • Cover Story: Fat chance for cancer cachexia

    By Lauren Martz, Staff Writer

    Fat chance for cancer cachexia

    With no drugs on the market and a pair of recent Phase III failures in cancer-associated cachexia, companies could be better off turning to the cause of the wasting disease rather than targeting its symptoms. Two independent academic teams have found evidence that browning of white fat is responsible for cachexia in patients with cancer and propose different strategies to block the process.

    Full Article
  • AstraZeneca taps the Cambridge wellspring

    AstraZeneca has unveiled plans for its R&D center and global headquarters in Cambridge, U.K. -- the next major step in the pharma's strategy to improve pipeline productivity to help it recover growth and regain ground in scientific leadership. The company hopes to tap into world-class research through partnerships with nearby institutes.

  • Corneal perspectives

    Two independent findings could increase the availability of tissue for corneal transplants. A UCSD team has identified key factors needed to culture the limbal stem cells necessary for clear vision. A Harvard team has found a marker for enhanced regenerative potential of limbal stem cells and licensed the antibody to stem cell companies Rheacell and Ticeba.

  • Circling back to basics

    Creating potent and orally bioavailable macrocycles is more challenging than developing small molecules, but a trio of studies could close the gap by proposing new design guidelines, identifying protein-protein interfaces to target and providing a new method to synthesize cyclic peptides.

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