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Browning fat Figure 1. Exercise messenger. Dana-Farber Cancer Institute researchers have identified a new hormone, irisin, which mediates some of the benefits exercise has on metabolism. Exercise induces increased …
Published on 2/2/2012
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Dana-Farber researchers have identified a hormone, irisin, that converts white fat into brown-like fat in mice. Ember Therapeutics has licensed the findings and is generating stabilized irisin variants for obesity and …
Published on 2/2/2012
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Japanese researchers have developed a method for creating large libraries of N-methylated peptide macrocycles. PeptiDream Inc. has exclusively licensed the technology and set up collaborations with six pharmas.
Published on 1/26/2012
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Macrocycles by the Trillions Figure 1. Making macrocycles RaPID-ly. A team from The University of Tokyo has developed a method called RaPID for generating libraries of trillions of N-methylated peptide macrocycles …
Published on 1/26/2012
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SciBX's roundup of 2011 public-private partnership data shows the emergence of New York as a translational hub, the impact of nongovernmental funding on infectious disease research compared with the more muted VC …
Published on 1/19/2012
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Spreadin' the News Figure 1. Breakdown of global public-private partnerships by companies (I) and institutions (II). Percentages are out of total number of public-private partnerships worldwide; bracketed values are …
Published on 1/19/2012
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Spreadin' the News Figure 2. Regional breakdown of companies and institutions involved in public-private partnerships in the top six U.S. states (I), top five European countries (II) and top five Asian countries (III…
Published on 1/19/2012
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Spreadin' the News Figure 3. Breakdown of therapeutic areas covered by seed or series A financing (I) and public-private partnerships in 2011 (II). For (I), percentages are out of total financing events across all …
Published on 1/19/2012
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Spreadin' the News Table 1. Leaders in the number of public-private partnerships. U.S. institutes were involved in over half of the reported public-private partnerships (PPPs) in 2011, with such institutes taking …
Published on 1/19/2012
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Spreadin' the News Table 2. Top five public-private partnerships by value. Three of the five largest public-private partnerships (PPPs) in 2011 are valued at $100 million or more. Listed PPPs do not include award and…
Published on 1/19/2012
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Spreadin' the News Table 3. Top five venture financing rounds for companies founded in 2011. The five largest series A rounds for companies founded in 2011 went to those with U.S. operations. Among the 31 companies …
Published on 1/19/2012
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A team led by Princeton researchers has shown that inhibiting vascular cell adhesion molecule-1/integrin alpha4 signaling could prevent bone metastases of breast cancer, thus handing companies with integrin alpha4 …
Published on 1/12/2012
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Researchers at Virginia Commonwealth University have found that inhibiting inflammasome formation with P2X7 antagonists could help prevent heart failure following acute myocardial infarction. The findings point to a …
Published on 1/5/2012
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No place like inflammasome Figure 1. Inflammasome activation pathway. Acute myocardial infarction (AMI) causes the release of danger signals including damage-associated molecular pattern molecules (DAMPs) and ATP in …
Published on 1/5/2012
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U.S. researchers have uncovered a mechanism by which melanomas expressing mutant BRAF acquire resistance to targeted drugs. The findings mark the first time a splice variant has been implicated in cancer drug resistance…
Published on 12/15/2011
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Big MAC attack in osteoarthritis Figure 1. Complement's vicious cycle in osteoarthritis. Joint damage can activate a self-perpetuating cycle of complement activation and cartilage damage that leads to osteoarthritis.…
Published on 12/8/2011
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An international team has shown that inhibiting the complement system could help slow disease progression in osteoarthritis, thus handing a potentially disease-modifying strategy to companies developing complement 5 …
Published on 12/8/2011
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Researchers from the Wellcome Trust Sanger Institute have identified a host receptor, basigin Ok blood group, that could be a good candidate for a vaccine against blood-stage malaria infection. The vaccine could be more…
Published on 12/1/2011
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A California team has shown that inhibiting MAGL reduces neuroinflammation in a mouse model of Parkinson's disease. The researchers are now investigating the small molecule's effects in other neurodegenerative and …
Published on 11/17/2011
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Dampening neuroinflammation Figure 1. Connecting cannabinoid and prostaglandin pathways. A team led by researchers from The Scripps Research Institute and the University of California, Berkeley have shown that …
Published on 11/17/2011
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Cover Story: Arrestin Psychosis Figure 1. Putting a bias into antipsychotics. A team from The University of North Carolina at Chapel Hill and Duke University has designed a class of antipsychotic compounds called b-…
Published on 11/10/2011
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Duke and UNC Chapel Hill researchers have used the drug Abilify as a scaffold to design a new class of antipsychotics that showed fewer side effects in mice. The researchers are negotiating a licensing deal for the …
Published on 11/10/2011
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Stanford researchers have developed a computational approach to analyzing CT scan images that they think could be better than biopsy for predicting patient response to targeted cancer therapies. The team now plans to …
Published on 11/3/2011
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German researchers have shown that tryptophan 2,3-dioxygenase can promote tumor progression and immune escape through the degradation of tryptophan into kynurenine, giving tumors a second immune escape pathway in …
Published on 10/27/2011
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Cover Story: Much ado about TDO Figure 1. Model for TDO-derived kynurenine signaling through AHR. The tryptophan metabolite kynurenine is an endogenous ligand for the aryl hydrocarbon receptor (AHR) that can promote …
Published on 10/27/2011