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  • Strategy: PD-1 matchmaking

    Courting combinations with PD-1

    A host of new targets in the tumor microenvironment could lead to combo therapies that turbo-boost PD-1 mAbs and expand their use, but matching targets and tumors will be the next challenge.

    Published on 1/29/2015
  • Figure: A cohort of co-inhibitors

    PD-1 matchmaking Strategy A cohort of co-inhibitors T cells in the tumor microenvironment express a range of co-inhibitor — or checkpoint — proteins that suppress T cell activity and block their antitumor effects. …

    Published on 1/29/2015
  • Table: Co-inhibitory and co-stimulatory targets

    PD-1 matchmaking Strategy Co-inhibitory and co-stimulatory targets Therapeutics targeting new co-inhibitory and co-stimulatory targets being explored as monotherapies or in combination with other co-inhibitory …

    Published on 1/29/2015
  • Targets & Mechanisms: Unearthing antibiotics

    New antimicrobial peptides from soil bacteria

    Two new techniques for exploiting soil bacteria to find antibiotics have uncovered compound classes and targets that could impact the field even more than the pair of antimicrobials discovered.

    Published on 1/22/2015
  • Box: Dirt Silk Road

    Unearthing antibiotics Targets & Mechanisms Dirt silk road Historically, soil-based bacteria were routinely mined for antibiotics, but the practice has lost ground to synthetic approaches involving structure-based …

    Published on 1/22/2015
  • Tools & Techniques: The right culture

    Mandating cell line validation addresses irreproducibility but poses challenges

    Stakeholders agree that mandating new methods to authenticate cell lines can improve reproducibility in research, but they don't agree on who should lead the charge.

    Published on 1/15/2015
  • Box: Journals take on reproducibility

    The right culture Tools & Techniques Journals take on reproducibility While any one journal cannot single-handedly mandate best practices to the entire research community, together they can promote consensus …

    Published on 1/15/2015
  • Strategy: Plenty of CRISPR pie

    Complex CRISPR IP may have little impact on therapeutic development

    The long term winners in the CRISPR space may have little to do with the impending IP brawl over the technology's inventorship

    Published on 1/8/2015
  • Figure: CRISPR burst

    Plenty of CRISPR pie Strategy CRISPR burst A burst of patent applications in 2014 and dramatic rise in publications related to therapeutic use of CRISPR has followed the publication in 2012 and early 2013 of the …

    Published on 1/8/2015
  • Neutralizing the negatives of RNAi

    The siRNN technology that Solstice licensed from UCSD could take RNAi-based therapies to tissues outside the liver and expand their use to a host of new diseases.

    Published on 12/18/2014
  • Figure 1: siRNA delivery free of charge

    Cover Story: Neutralizing the negatives of RNAi Figure 1. siRNA delivery free of charge. Short interfering ribonucleic neutrals (siRNNs) are a class of RNAi prodrugs that solve the delivery limitations of standard …

    Published on 12/18/2014
  • Universal reversal for heparin

    A synthetic, universal heparin reversal agent could provide a lower-risk option for preventing bleeding during surgery than protamine, the standard of care, but finding industry partners could be the challenge.

    Published on 12/11/2014
  • Figure 1: Structure of synthetic UHRAs

    Cover Story: Universal reversal for heparin Figure 1. Structure of synthetic UHRAs. Researchers from The University of British Columbia have developed synthetic dendrimer polymers as universal heparin reversal agents…

    Published on 12/11/2014
  • Figure 1: Solving a family problem

    Cover Story: GPCRs' grand plans Figure 1. Solving a family problem. The GPCR Consortium aims to solve at least 200 unknown structures of GPCRs. The GPCR superfamily contains 826 members, identified based on sequence…

    Published on 12/4/2014
  • GPCRs' grand plans

    A public-private precompetitive consortium aims to expand the number of known GPCR structures from 26 to over 200.

    Published on 12/4/2014
  • Tapping TOPK

    OncoTherapy Science has a potent TOPK inhibitor in a liposomal formulation that avoids the toxicity of other cytokinesis-targeted compounds.

    Published on 11/20/2014
  • Table 1: Adjuvant discovery contracts

    Cover Story: Boosting adjuvants Table 1. Adjuvant discovery contracts. The NIH has awarded contracts totaling more than $70 million for 7 new adjuvant discovery projects. Amounts shown represent the potential …

    Published on 11/13/2014
  • Table 2: Selected adjuvants and adjuvanted vaccines for infectious disease

    Cover Story: Boosting adjuvants Table 2. Selected adjuvants and adjuvanted vaccines for infectious disease. Although many marketed vaccines for infectious diseases use alum as an adjuvant, there are three marketed …

    Published on 11/13/2014
  • Boosting adjuvants

    The NIH is committing $70 million to creating new adjuvants that can work with different types of vaccines and wants industry to get involved.

    Published on 11/13/2014
  • A conversation with Elias Zerhouni

    Sanofi's Elias Zerhouni wants a dedicated national fund to keep young scientists involved in research, which he thinks should be the top policy priority for advancing biomedical innovation.

    Published on 11/6/2014
  • Redistributing BRD4 in inflammation

    A new link between inflammation and atherosclerosis centers on the BET bromodomain protein BRD4 and could provide new targets for intervention.

    Published on 10/30/2014
  • Figure 1: Molecular mechanism of BRD4-regulated inflammation

    Cover Story: Redistributing BRD4 in inflammation Figure 1. Molecular mechanism of BRD4-regulated inflammation. As reported in Brown et al., inflammatory stimuli induce rapid genomewide redistribution of bromodomain …

    Published on 10/30/2014
  • Diagnosing resistance

    The frontier for combating antibiotic resistance is now in developing fast, sensitive and versatile diagnostics that can improve treatment and optimize clinical trials.

    Published on 10/23/2014
  • Figure 1: Venture financing for therapies and diagnostics for bacterial infections

    Cover Story: Diagnosing resistance Figure 1. Venture financing for therapies and diagnostics for bacterial infections. (I) Total amount of venture financing for newly formed companies developing therapies or …

    Published on 10/23/2014
  • Table 1: Selected diagnostic tests in development for bacterial infections

    Cover Story: Diagnosing resistance Table 1. Selected diagnostic tests in development for bacterial infections. Diagnostics are listed from most to least advanced stage of development. Source: BCIQ: BioCentury Online…

    Published on 10/23/2014

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